MIT DEM RISIKO VON OBESITÄT UND TYP-2-DIABETES ASSOZIIERTER HAPLOTYP DES GENS ENPP1 (PC1) UND ANWENDUNGEN DAVON
摘要
The present invention is directed to a method for determining if a subject is at increased risk to develop obesity or pathology related to obesity by determining the presence of a haplotype comprising three specific SNPs in a DNA or RNA sample of this subject and/or an elevated serum ENPP1 protein concentration. The present invention also relates to a kit and to an isolated nucleic sequence, vector or recombinant cell comprises said ENPPI gene haplotype. The invention further comprises a method for selecting a compound for the treatment or the prevention of obesity or pathology related to obesity and a method for determining the efficacy of a drug to reduce the risk of obesity or pathology related to obesity in a patient.
申请公布号
AT449192(T)
申请公布日期
2009.12.15
申请号
AT20060763749T
申请日期
2006.06.15
申请人
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);UNIVERSITE DU DROIT ET DE LA SANTE DE LILLE 2
发明人
FROGUEL, PHILIPPE;MEYRE, DAVID;DINA, CHRISTIAN;BOUTIN, PHILIPPE