发明名称 |
Method of treating a muscle-related condition with modified IGF1 polypeptides |
摘要 |
A targeting fusion protein comprising a component that comprises a (i) ligand or derivative or fragment thereof that binds a pre-selected target surface protein, such as a receptor, and (ii) an active agent or therapeutic agent(s), and further optionally (iii) a multimerizing component and/or (iv) a signal sequence. In a preferred embodiment, the targeting fusion polypeptide targets muscle and is useful to treat a muscle-related disease or condition, such as muscle atrophy.
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申请公布号 |
US7632503(B2) |
申请公布日期 |
2009.12.15 |
申请号 |
US20080070213 |
申请日期 |
2008.02.14 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
STITT TREVOR;LATRES ESTHER;GLASS DAVID J. |
分类号 |
A61K39/395;A61K38/00;A61K38/27;A61K38/30;C07H21/04;C07K14/475;C07K14/65;C07K14/705;C07K16/46;C12N15/62;C12P21/06 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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