| 摘要 |
PURPOSE: A therapeutic agent containing a compound as an active ingredient for treating inflammatory disease is provided to suppress generation of inflammatory media such as NO(nitrogen oxide), IL-6(interleukin-6) and TNF-α(tumor necrosis factor-alpha) in LPS-activated RAW 264.7 cell. CONSTITUTION: A therapeutic agent for treating inflammatory diseases contains a compound of the chemical formula 1 as an active ingredient. In chemical formula 1, R is COOH, COOCH3, CH2OH or CH2NHCOCF3, R1 and R2 is H, C6H5, or Br, and m is 1-5 integer and n is 1-4 integer. The compound of chemical formula 1 is (E)-11-oxooctadeca-9-enole, (E)-10- oxooctadeca-8-enole, (E)-9-oxooctadeca-10-enole or (E)-8-oxooctadeca-9-enole. The inflammatory diseases are rheumatoid arthritis, inflammatory bowel disease, osteoporosis, psoriasis, or toxic shock syndrome.
|
