| 摘要 |
The present invention provides compounds, compositions and methods for promoting bone growth. Compounds useful in the methods of the present invention include compounds of Formula 1, wherein each R1 and R2 is H, halogen, C1-6 alkyl, C1-6 alkoxy, C 1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkoxy, -OR4, -NR4R5, -SR4, -C(O)R4, -C(O)OR4, -C(O)NR4R5, -N(R4)C(O)R5, -N(R4)C(O)OR5, -N(R4JC(O)NR4R5, -OP(O)(OR4)2, -S(O)2OR4, -S(O)2NR4R5, -CN, cycloalkyl, heterocycloalkyl, aryl or heteroaryl. Each R4 and R5 is H or C1-6 alkyl. X is O, S or NR4. Y is an aryl ring system having 6-10 ring members or a heteroaryl ring system having 5-10 ring members where 1-3 ring members are each N, O or S. Subscript n is 1 or 2. The compounds also include salts, hydrates and isomers of the compounds of the present invention. |
