PLURIPOTENCY ASSOCIATED EPIGENETIC FACTOR

摘要

A method for controlling the pluripotent phenotype of a cell comprising modulating the expression or activity of a ESET/SETDB1 polypeptide, or a homologue thereof, within the cell is provided. Pluripotent cells, cultures of such cells and methods for reprogramming somatic cells to a pluripotent phenotype comprising expressing a ESET/SETDB1 polypeptide in the cells, either alone or in combination with other pluripotency factors, are further provided. Methods for identifying modulators of pluripotency and their use in treating cancer or cancer stem cells are also provided.