发明名称 |
Novel chimeric plasminogen activators and their pharmaceutical use |
摘要 |
The present invention relates to recombinant chimeric proteins comprising a surfactant protein precursor N-terminally fused to a plasminogen activator or comprising a mature surfactant protein N-terminally or C-terminally fused to a plasminogen activator. The invention is also directed to the corresponding nucleic acid molecules encoding such fusion proteins as well as to a method for their production. The invention further refers to a pharmaceutical composition comprising such a fusion protein and to pharmacological uses of an inventive fusion protein for the prevention and/or treatment of inflammatory and interstitial lung diseases.
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申请公布号 |
US2009305961(A1) |
申请公布日期 |
2009.12.10 |
申请号 |
US20030583785 |
申请日期 |
2003.12.18 |
申请人 |
SEEGER WERNER;GUENTHER ANDREAS;RUPPERT CLEMENS;MARKART PHILIPP;MAGDOLEN VIKTOR;WEAVER TIMOTHY E |
发明人 |
SEEGER WERNER;GUENTHER ANDREAS;RUPPERT CLEMENS;MARKART PHILIPP;MAGDOLEN VIKTOR;WEAVER TIMOTHY E. |
分类号 |
A61K38/17;A61P29/00;C07H21/04;C07K14/435;C07K14/785;C12N5/10;C12N9/72;C12N15/63;C12P21/00 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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