发明名称 |
MICRO-FLUIDIC DEVICE FOR MEASUREMENTS OF CELL MIGRATION IN RESPONSE TO CHEMICAL STIMULI |
摘要 |
The invention relates to a device for making measurements of the migration of cells in response to exposure to a gradient of concentration of a chemoat tractive substance (chemotaxis). In particular, the invention relates to a device comprising a first site designed to receive a specimen of cells, and at least one second site designed to receive a substance potentially capable of influencing chemotaxis, wherein the first and second sites are fluidically connected together by a containing duct, and are arranged along an axis A directed between the first site and the second site with a non-uniform density, a plurality of obstacle elements that create along the duct a gradient in the free section of passage at the disposal of the cells, which is defined by a corresponding plurality of micro- channels directed parallel to the axis A and having a pre-set transverse dimension d. |
申请公布号 |
WO2009147486(A2) |
申请公布日期 |
2009.12.10 |
申请号 |
WO2009IB05712 |
申请日期 |
2009.05.25 |
申请人 |
TECHFAB S.R.L.;PIZZI, MARCO;HIRSCH, EMILIO;COSTA, CARLOTTA;VITIELLO, ELISA |
发明人 |
PIZZI, MARCO;HIRSCH, EMILIO;COSTA, CARLOTTA;VITIELLO, ELISA |
分类号 |
C12M1/34;B01L3/00 |
主分类号 |
C12M1/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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