发明名称 |
INHIBITION OF QUORUM SENSING-MEDIATED PROCESSES IN BACTERIA |
摘要 |
<p>Methods are provided for identifying molecules that can be used to positively and negatively manipulate quorum-sensing-mediated communication to control bacterial behavior. Small-molecule antagonists that disrupt quorum-sensing-mediated activities are identified. Methods are provided for disrupting detection of acyl- homoserine lactone autoinducer in Gram-negative bacteria by contacting the bacteria with the antagonists. Methods of inhibiting quorum sensing-mediated activity in Gram-negative bacteria are provided wherein the activity is pathogenicity, bioluminescence, siderophore production, type III secretion, or metalloprotease production.</p> |
申请公布号 |
WO2009148571(A1) |
申请公布日期 |
2009.12.10 |
申请号 |
WO2009US03348 |
申请日期 |
2009.06.02 |
申请人 |
THE TRUSTEES OF PRINCETON UNIVERSITY;BASSLER, BONNIE;SWEM, LEE |
发明人 |
BASSLER, BONNIE;SWEM, LEE |
分类号 |
C12Q1/18;A61K31/40 |
主分类号 |
C12Q1/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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