发明名称 |
OLIGONUCLEOTIDE DUPLEXES COMPRISING DNA-LIKE AND RNA-LIKE NUCLEOTIDES AND USES THEREOF |
摘要 |
Novel oligonucleotide pairs which can form a duplex comprising one or more DNA-like nucleotides (e.g., 2'-substituted arabinonucleotides (ANA)); in combination with one or more RNA-like nucleotides (e.g., 2'-substituted ribonucleotides (RNA) and/or locked nucleic acid nucleotides (LNA)), are disclosed. The use of such oligonucleotide duplexes, such as for silencing the expression of a nucleic acid or gene of interest using small interfering RNA (siRNA) technologies, is also disclosed. |
申请公布号 |
CA2764456(A1) |
申请公布日期 |
2009.12.10 |
申请号 |
CA20092764456 |
申请日期 |
2009.06.05 |
申请人 |
LABOPHARM INC. |
发明人 |
DAMHA, MASAD JOSE;WATTS, JONATHAN K.;DELEAVEY, GLEN |
分类号 |
C12N15/11;A61K31/713;A61K48/00;C07H21/00;C07H21/02;C12N15/63 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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