发明名称 |
FVIII MUTEINS FOR TREATMENT OF VON WILLEBRAND DISEASE |
摘要 |
This invention relates to treatment of von Willebrand Disease by administration of Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties in subjects lacking von Willebrand Factor.
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申请公布号 |
CA2726942(A1) |
申请公布日期 |
2009.12.10 |
申请号 |
CA20092726942 |
申请日期 |
2009.06.04 |
申请人 |
BAYER HEALTHCARE LLC |
发明人 |
JIANG, HAIYAN;PIERCE, GLENN;MURPHY, JOHN E.;PAN, JUNLIANG;ZHANG, XIN;LIU, TONGYAO |
分类号 |
A61K47/48;A61K38/37;A61P7/04;C07K14/755;C07K17/08 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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