发明名称 |
GENE EXPRESSED IN PROSTATE CANCER AND METHODS OF USE |
摘要 |
A polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Splice Variant-Novel Gene Expressed in Prostate (SV-NGEP). Polynucleotides encoding SV-NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugates are disclosed that specifically bind SV-NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP. Assays are disclosed for the detection prostate cancer. Pharmaceutical compositions including an SV-NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.
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申请公布号 |
US2009304702(A1) |
申请公布日期 |
2009.12.10 |
申请号 |
US20090497382 |
申请日期 |
2009.07.02 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE |
发明人 |
PASTAN IRA;BERA TAPAN K.;LEE BYUNGKOOK |
分类号 |
A61K39/395;A61K38/00;A61K38/16;A61K47/48;C07K14/47;C07K16/00;C12N5/02;C12Q1/68;G01N33/53;G01N33/574 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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