发明名称 |
CYTOTOXIC T-CELL EPITOPE PEPTIDES THAT SPECIFICALLY ATTACK EPSTEIN-BARR VIRUS-INFECTED CELLS AND USES THEREOF |
摘要 |
The present inventors introduced mRNAs for the Epstein-Barr virus proteins LMP1 and EBNA1 into antigen-presenting cells, and as a result, demonstrated that the cells induced Epstein-Barr virus-specific cytotoxic T cells. The present inventors also demonstrated that the cytotoxic T cells recognized epitope peptides presented via HLA-A*0206, HLA-Cw*0303, or HLA-Cw*0304, inhibited the outgrowth of Epstein-Barr virus-infected B cells, and lysed Epstein-Barr virus-infected NK lymphomas and NK cells.
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申请公布号 |
US2009305324(A1) |
申请公布日期 |
2009.12.10 |
申请号 |
US20060091705 |
申请日期 |
2006.10.27 |
申请人 |
MEDICAL AND BIOLOGICAL LABORATORIES CO., LTD;AICHI PREFECTURE |
发明人 |
KUZUSHIMA KIYOTAKA;ITO YOSHINORI;OKAMURA AYAKO;AKATSUKA YOSHIKI;MORISHIMA YASUO |
分类号 |
C12Q1/02;C07H21/00;C07K7/06;C12N5/06 |
主分类号 |
C12Q1/02 |
代理机构 |
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