CONJUGATED DOUBLE STRAND COMPOSITIONS FOR USE IN GENE MODULATION

摘要

The present invention provides conjugated double stranded compositions wherein each strand is modified to have a motif defined by positioning of beta-D-ribonucleosides and/or sugar modified nucleosides. More particularly, the present compositions comprise a linked conjugate group on one strand and a non hybridizing region of 2'-modified nucleosides on the other strand. Each strand further comprises one or more phosphorothioate internucleoside linkage. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.