TABLETS WITH IMPROVED DRUG SUBSTANCE DISPERSIBILITY

摘要

The present invention relates to a method for the preparation of pharmaceutical compositions in the form of tablets with improved drug substance dispersibility, which method comprises a) preparing a dispersion of at least one pharmaceutically active drug substance and at least one surfactant and/or binder in a liquid; b) preparing a carrier by dry blending at least one porous carrier and one or more excipient(s); and c) spray granulating the dispersion prepared in step a) onto the carrier prepared in step b) to obtain a spray-granulated product.