发明名称 |
COMPOUNDS THAT INHIBIT HIF-1 ACTIVITY, THE METHOD FOR PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION CONTAINING THEM AS AN EFFECTIVE COMPONENT |
摘要 |
Disclosed herein are an HIF-1 inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient. The HIF-1 inhibitor shows anticancer activity thanks to the inhibition activity against HIF-1, a transcription factor which plays an important role in the growth and metastasis of cancer, but not to general cytotoxicity. Thus, the HIF-inhibitor and a pharmaceutically acceptable salt thereof can be used as a therapeutic for various cancers such as liver cancer; stomach cancer and breast cancer. Also, the compound having inhibition activity against HIF-1 is useful in the treatment of diabetic retinopathy and arthritis, which are aggravated by HIF-1-mediated VEGF expression.
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申请公布号 |
US2009306078(A1) |
申请公布日期 |
2009.12.10 |
申请号 |
US20070306319 |
申请日期 |
2007.07.03 |
申请人 |
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY |
发明人 |
LEE JUNG JOON;LEE JEONG-HYUNG;LEE KYEONG;HONG YOUNG-SOO;SHANTHAVEERAPPA B.K.;JIN YINLAN;KIM JIN HWAN;JIN XUEJUN |
分类号 |
A61K31/5377;A61K31/167;A61K31/41;A61K31/423;A61P19/02;C07C233/33;C07D257/04;C07D263/57;C07D295/15 |
主分类号 |
A61K31/5377 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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