发明名称 |
THERAPY DELIVERY AND MONITORING USING A GENE OF INTEREST-REPORTER FUSION PROTEIN AND OPTICAL IMAGING |
摘要 |
<p>The present invention relates to a method of non-invasively monitoring the expression of a gene of interest in a cell when contacting said cell with a compound influencing the expression of said gene of interest. The present invention is also concerned with different isolated nucleic acid molecules comprising a coding sequence. Said coding sequence comprises a gene of interest-sequence encoding a gene of interest-polypeptide fused to a reporter sequence encoding a fluorescent reporter polypeptide and is operatively coupled to a promoter sequence. The present invention is also concerned with the use of a method and a nucleic acid molecule of the invention for delivering a compound influencing the expression of a gene of interest in a cell, monitoring the delivery of said compound as well as monitoring the influence on the expression of said gene of interest induced by said compound at the same time.</p> |
申请公布号 |
WO2009147549(A1) |
申请公布日期 |
2009.12.10 |
申请号 |
WO2009IB52010 |
申请日期 |
2009.05.14 |
申请人 |
KONINKLIJKE PHILIPS ELECTRONICS N. V.;DIMITROVA, NEVENKA;MITTAL, CHETAN |
发明人 |
DIMITROVA, NEVENKA;MITTAL, CHETAN |
分类号 |
C12N15/62;C07K14/435;C07K14/71;C12Q1/68;G01N33/50 |
主分类号 |
C12N15/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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