CALCIUM-ACTIVATED CHLORIDE CHANNEL AND METHODS OF USE THEREOF

摘要

The present invention provides a cloned, isolated calcium-activated chloride channel, and a polynucleotide comprising a nucleotide sequence encoding the channel. The present invention further provides a genetically modified cell comprising a subject polynucleotide, and use of the cells to identify agents that modulate calcium-activated chloride channel activity. The present invention further provides genetically modified cells and non-human animals that do not express a subject calcium-activated chloride channel.