发明名称 Use Of Low Doses Of Oligonucleotides Antisense To TGF-Beta, VEGF, Interleukin-10, C-Jun, C-Fos Or Prostaglandin E2 Genes In The Treatment Of Tumors
摘要 This invention is related to the use of at least one oligonucleotide with a length of from about 8 to about 30 nucleotide building blocks for manufacturing a pharmaceutical preparation for the prophylaxis and/or the treatment of diseases, that are modulated by TGF-beta2, TGF-beta1, TGF-beta3, VEGF, interleukin-10, c-jun, c-fos, and/or prostaglandin E2 in a mammal, wherein said oligonucleotide hybridizes with a messenger RNA of a TGF-beta2, TGF-beta1, TGF-beta3, VEGF, interleukin-10, c-jun, c-fos and/or prostaglandin E2 gene and wherein said preparation comprises said oligonucleotide in a concentration of about 1 microM to about 25 microM.
申请公布号 US2009306176(A1) 申请公布日期 2009.12.10
申请号 US20060792041 申请日期 2006.05.04
申请人 SCHLINGENSIEPEN KARL-HERMANN;SCHLINGENSIEPEN REIMAR 发明人 SCHLINGENSIEPEN KARL-HERMANN;SCHLINGENSIEPEN REIMAR
分类号 A61K31/7105;A61K31/7088;C12N15/11;C12N15/113 主分类号 A61K31/7105
代理机构 代理人
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