NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE WHICH HAS, AS SUBSTITUENT, PHENYL GROUP HAVING SULFONIC ACID ESTER STRUCTURE OR SULFONIC ACID AMIDE STRUCTURE INTRODUCED THEREIN AND HAS GLUCOCORTICOID RECEPTOR-BINDING ACTIVITY.

摘要

Disclosed is a compound represented by the general formula (1) or a salt thereof, which is useful as a modulator for a glucocorticoid receptor. In the formula, R1 represents a lower alkyl group, a lower cycloalkyl group, an aryl group or the like; R2 represents a hydrogen atom, a lower alkyl group or the like; R3 represents a hydrogen atom, a lower alkyl group or the like; R4 and R5 independently represent a hydrogen atom, a lower alkyl group or the like; R6 represents a hydrogen atom, a lower alkyl group or the like; R7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group or the like; W represents an oxygen atom, a sulfur atom, NR8 or the like; R8 represents a hydrogen atom, a lower alkyl group or the like; X represents an oxygen atom or a sulfur atom; Y represents a lower alkylene group or the like; Z represents an oxygen atom, a sulfur atom, NR9, OCO or OSO2; and R9 represents a hydrogen atom, a lower alkyl group or the like.