ANTI-EGFR SINGLE-CHAIN FVS AND ANTI-EGFR ANTIBODIES

摘要

This invention relates to new anti-EGFR antibodies and single-chain Fvs (scF vs) thereof which can be obtained from phage-antibody libraries constructed from cells of an immunized mammalian, preferably a mou se. Two of the single-chain Fvs isolated from the phage- antibody libraries were engineered to create partially humanized whole antib ody molecules These chimeric anti-EGFR antibodies contain constant regions of human immunoglobulins and can be used as well as the sin gle-chain Fvs as agents for the diagnosis and therapy of human tumors.