发明名称 |
A METHOD FOR SELECTIVE EXPRESSION OF THERAPEUTIC GENES BY HYPERTHERMIA |
摘要 |
A method for controlling in vivo heat-inducible gene expression for provision of therapeutic polypeptide. The method includes the steps of: (a) providing a construct comprising a polynucleotide encoding a therapeutic polypeptide, wherein the polynucleotide is operatively linked to a heat-inducible promoter; (b) administering the construct to a warm-blooded vertebrate at a site at or near the tumor; and (c) applying heat to the site at or near the tumor to express the therapeutic polypeptide, whereby anti-tumor activity is observed.
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申请公布号 |
CA2349506(C) |
申请公布日期 |
2009.12.08 |
申请号 |
CA20012349506 |
申请日期 |
2001.06.15 |
申请人 |
DUKE UNIVERSITY |
发明人 |
LI, CHUAN-YUAN;HUANG, QIAN;DEWHIRST, MARK W. |
分类号 |
A61K48/00;A61K38/19;A61K38/20;C12N15/861 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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