FAT-SOLUBLE VITAMIN-DERIVED NOVEL CATIONIC CHITOSAN, A PREPARATION METHOD OF THE SAME AND A DRUG DELIVERY SYSTEM COMPRISING THE SAME

摘要

PURPOSE: A cationic chitosan derivative which is bound with lipid-soluble vitamin or its derivative is provided to enhance the efficiency of transporting pharmaceutically effective ingredient into cells and improve treatment efficiency of the effective ingredient. CONSTITUTION: A cationic chitosan derivative has a structure of the chemical formula 1 or 2. The cationic chitosan derivative is prepared by reacting chitosan with lipid soluble vitamin using a coupling agent or protection group under the presence of a solvent. The protection group is phthalic anhydride. The reaction is performed under the presence of nucleophilic catalyst, DMAP[4-(Dimethylamino)pyridine]. A drug delivery system contains pharmaceutically effective ingredient and cationic chitosan derivative. The pharmaceutically effective ingredient is oligo nucleic acid. The drug delivery system has the form of liposome, micelle, emulsion, or nanoparticle.