摘要 |
Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH 2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covale nt bond, CH2, and CH2CH2; Z is selected from the group consisting of CH2, CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h) , (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.
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申请人 |
ABBOTT LABORATORIES |
发明人 |
DAANEN, JEROME F.;SCHRIMPF, MICHAEL R.;RYTHER, KEITH B.;MEYER, MICHAEL D.;BUNNELLE, WILLIAM H.;DART, MICHAEL J.;SIPPY, KEVIN B.;CRISTINA, DANIELA BARLOCCO;TOUPENCE, RICHARD B. |