CO-CRYSTALS OF ATORVASTATIN HEMI-CALCIUM AND BUTANONE, THE PREPARATION PROCESSES AND USES AS HMG-COA ENZYME INHIBITOR THEREOF

摘要

Co-crystals of atorvastatin hemi-calcium and butanone, the preparation processes and uses as HMG-CoA enzyme inhibitor thereof. The dihydrate formed from atorvastatin hemi-calcium and butanone of formula I and water exists in the steady crystal form(crystal H) whose water-solubility(0.46 mg/ml) is far higher than that of atorvastatin hemi-calcium trihydrate available from market as the later's is only 0.198 mg/ml under the same testing conditions.