发明名称 |
Rekombinante proteiner av en Pakistani stamme av hepatitt E og deres anvendelse i diagnostiske metoder og vaksiner |
摘要 |
A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.
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申请公布号 |
NO971529(A) |
申请公布日期 |
1997.05.26 |
申请号 |
NO19970001529 |
申请日期 |
1997.04.03 |
申请人 |
GOVERNMENT OF THE UNITED STATES OF AMERICA REP BY THE SECRETARY. DEPARTMENT OF HEALTH AND HUMAN SERVICES. OFFICE OF TECHNOLOGY TRANSFER. NATIONAL INST OF HEALTH, THE |
发明人 |
TSAREV, SERGEI A.;EMERSON, SUZANNE U.;PURCELL, ROBERT H. |
分类号 |
G01N33/576;A61K35/76;A61K39/00;A61K39/29;A61K39/395;A61K48/00;A61P31/12;C07K14/08;C07K16/10;C12N1/19;C12N5/10;C12N7/00;C12N15/00;C12N15/09;C12P21/02;C12P21/08;C12R1/84;C12R1/91;C12R1/92 |
主分类号 |
G01N33/576 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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