摘要 |
<p>The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative disorder, thrombosis, allergy, asthma, rheumatoid arthritis, leukemia, or non-Hodgkin's lymphoma.</p> |
申请人 |
PORTOLA PHARMACEUTICALS, INC.;BAUER, SHAWN, M.;JIA, ZHAOZHONG, J.;SONG, YONGHONG;XU, QING;MEHROTRA, MUKUND;ROSE, JACK, W.;HUANG, WOLIN;VENKATARAMANI, CHANDRASEKAR;PANDEY, ANJALI |
发明人 |
BAUER, SHAWN, M.;JIA, ZHAOZHONG, J.;SONG, YONGHONG;XU, QING;MEHROTRA, MUKUND;ROSE, JACK, W.;HUANG, WOLIN;VENKATARAMANI, CHANDRASEKAR;PANDEY, ANJALI |