发明名称 ANTIBODY FRAGMENT IMITATING T-CELL RECEPTOR AND METHOD FOR PRODUCING THE SAME
摘要 <P>PROBLEM TO BE SOLVED: To provide a means or the like for quantitatively and sequentially analyzing what kinds of presentation action, CTL response and the like are exhibited on an infected cell by an antigen presenting a peptide derived from an HIV virus or the like, and understanding an HIV infection-controlling mechanism of the CTL. <P>SOLUTION: The peptide includes an antibody variable region having an amino acid sequence of each CDR region of TCR in each corresponding CDR region. Each kind of the antibodies includes the polypeptide as a constituent component, and has the antigen-recognizing ability similar to the TCR. The method for producing them, the probe for a complex of the HLA and a target antigen peptide, and the detection means or the detection reagent are also provided. <P>COPYRIGHT: (C)2010,JPO&INPIT
申请公布号 JP2009278927(A) 申请公布日期 2009.12.03
申请号 JP20080135007 申请日期 2008.05.23
申请人 TOHOKU UNIV;KUMAMOTO UNIV 发明人 KUMAGAI IZUMI;UMETSU MITSUHISA;WATANABE HIDEKI;UENO TAKAMASA;MOTOZONO CHIHIRO
分类号 C12N15/09;A61K39/00;A61K39/395;A61P31/18;C07K14/705;C07K16/10;C07K19/00;C12P21/02;C12P21/08;G01N33/53 主分类号 C12N15/09
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