发明名称 |
CONJUGATES OF BIOLOGICALLY ACTIVE PROTEINS HAVING A MODIFIED IN VIVO HALF-LIFE |
摘要 |
Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide.
|
申请公布号 |
US2009298762(A1) |
申请公布日期 |
2009.12.03 |
申请号 |
US20080251324 |
申请日期 |
2008.10.14 |
申请人 |
CELL THERAPEUTICS, INC. |
发明人 |
BESMAN MARC;CHIPMAN STEWART;LEUNG DAVID;SINGER JACK |
分类号 |
A61K38/16;A61K38/05;A61K38/06;A61K38/07;A61K38/08;A61K38/10;A61P43/00;C07H21/00;C07K5/00;C07K7/00;C07K7/06;C07K7/08;C07K14/00;C07K14/52;C07K14/54;C07K14/555;C07K14/575;C07K14/61;C07K14/745;C07K16/18;C12N1/16;C12N1/21;C12N5/06;C12N9/00;C12N9/50;C12N15/74;C12P21/02;G01N33/48 |
主分类号 |
A61K38/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|