发明名称 |
Method to Assess Stability of Proteins |
摘要 |
A method for determining conformational stability of proteins detects the change in free sulfhydryls accessible to reaction with a fluorescent probe after combined chemical and thermal denaturation. The method is useful in any application where the stability and integrity of a protein preparation is useful information. The method can be used to screen protein variants for desirable stability profile.
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申请公布号 |
US2009298186(A1) |
申请公布日期 |
2009.12.03 |
申请号 |
US20090394714 |
申请日期 |
2009.02.27 |
申请人 |
BRIGHAM-BURKE MICHAEL;LACY EILYN R |
发明人 |
BRIGHAM-BURKE MICHAEL;LACY EILYN R. |
分类号 |
G01N33/68 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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