发明名称 |
VERFAHREN ZUR CHEMISCHEN SYNTHESE CHIMÄRISCHER IMMUNGLOBULINPROTEINE |
摘要 |
A chimeric protein is synthesized by a) recombinantly expressing a fusion protein comprising at least a portion of an immunoglobulin constant region and a splicing protein capable of forming a C terminus thioester on the portion of an immunoglobulin constant region; b) adding a thiol cofactor to the fusion protein of a); and c) adding at least one biologically active molecule having an N terminal cysteine. |
申请公布号 |
DE602004023724(D1) |
申请公布日期 |
2009.12.03 |
申请号 |
DE20046023724T |
申请日期 |
2004.05.06 |
申请人 |
SYNTONIX PHARMACEUTICALS INC. |
发明人 |
MEZO, ADAM R.;PETERS, ROBERT T. |
分类号 |
C07K1/02;A61K38/00;A61K39/395;C07H21/04;C07K1/06;C07K1/10;C07K1/107;C07K14/475;C07K14/505;C07K14/555;C07K14/56;C07K14/565;C07K14/745;C07K16/00;C07K16/44;C07K16/46;C12N;C12N5/06;C12N9/64;C12P21/00;C12P21/04 |
主分类号 |
C07K1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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