摘要 |
Compounds selected from the group which consists of the compounds of formula (I), wherein each of X1 and X2, which are the same or different, is halogen or a C1-3 alkoxy group, R1 is H, CF3 or a C1-3 alkyl group, R2 is a hydrogen atom or an OH group, A is group (a), (b) or (c), B is a single bond, -CO-, -CO-CH2-, -CO-CH2-O-, -CO-CH=CH or -SO2-, m is 2 or 3, n is 0, 1, 2 or 3, R3 is a hydrogen atom or a methyl group, and W is CH or N, the amidine group C(=NR2)NH2 being in the 2, 3 or 4 position on the aromatic ring, and addition salts thereof, are disclosed. A method for preparing said compounds, and the therapeutical use thereof, particularly for treating diseases in which bradykinin is involved, are also disclosed.
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申请人 |
FOURNIER INDUSTRIE ET SANTE;DODEY, PIERRE;BONDOUX, MICHEL;HOUZIAUX, PATRICK;BARTH, MARTINE;OU, KHAN |
发明人 |
DODEY, PIERRE;BONDOUX, MICHEL;HOUZIAUX, PATRICK;BARTH, MARTINE;OU, KHAN |