METHOD FOR TREATING WOUNDS BY ADMINISTERING FULLERENES

摘要

Disclosed herein are methods for treating wounds. In one embodiment, the method comprises: administering to a subject in need thereof a therapeutically effective amount of a synthetically modified fullerene of the formula Zm-F-Yn wherein F is a fullerene of formula Cp or X@Cp, the fullerene having two opposing poles and an equatorial region; Cp represents a fullerene cage having p carbon atoms, and X@CP represents such a fullerene cage having a chemical group X within the cage; Z and Y are positioned near respective opposite poles of Cp; m = 1- 5 and Z is a hydrophilic, lipophilic, or amphiphilic chemical moiety; n = 1-5 and Y is a lipophilic chemical moiety; p = 60-200 and p is an even number; and X, if present, represents one or more metal atoms within the fullerene (F), optionally in the form of a trinitride of formula Gi=1-3Hk=3-iN in which G and H are metal atoms.