发明名称 |
PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE |
摘要 |
<p>Purine compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.</p> |
申请公布号 |
WO2009146406(A1) |
申请公布日期 |
2009.12.03 |
申请号 |
WO2009US45603 |
申请日期 |
2009.05.29 |
申请人 |
GENENTECH, INC.;F. HOFFMANN-LA ROCHE AG;CASTANEDO, GEORGETTE;CHUCKOWREE, IRINA;FOLKES, ADRIAN;SUTHERLIN, DANIEL, P.;WAN, NAN CHI |
发明人 |
CASTANEDO, GEORGETTE;CHUCKOWREE, IRINA;FOLKES, ADRIAN;SUTHERLIN, DANIEL, P.;WAN, NAN CHI |
分类号 |
C07D473/32;A61K31/52;A61P35/00 |
主分类号 |
C07D473/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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