| 摘要 |
<p>Human T-lymphotropic virus type-1 (HTLV-1) is the etiologic agent of Adult T-cell leukemia, an aggressive CD4+/CD25+ T cell malignancy. The early molecular events induced by HTLV-1 in the induction of leukemia are unknown predominantly due to the lack of an animal model which recapitulates ATL development. HTLV-1 is capable of infecting CD34+ HPCs and these cells serve as a reservoir for HTLV-1 infection in vivo. HTLV-1 infection of humanized NOD/SCID mice (HTLV-1-NOD/SCID-Hu) was achieved by HTLV-1 infection and inoculation of NOD/SCID mice with infected CD34+ HPCs. A majority of infected mice develop CD4+CD25+ T lymphoma with clinical characteristic associated with the ATL. Leukemic cells are engrafted in naïve NOD/SCID mice following intraperitoneal injection. The HTLV-1-NOD/SCID-Hu model permits investigations and characterization of pre-leukemic events resulting in the manifestation of ATL and is important in the development of novel therapeutics.</p> |
