FLEXIBLE, POLYVALENT ANTIVIRAL DENDRIDIC CONJUGATES FOR THE TREATMENT OF HIV/AIDS AND ENVELOPED VIRAL INFECTION

摘要

The invention provides flexible antiviral conjugates that exhibit exceptional antiviral activity, including activity against HIV and against drug-resistant HIV strains. Conjugates of the invention include a low molecular weight, flexible scaffold and at least one binding moiety such as a human cell membrane protein which binds to one or more viral surface proteins of an enveloped virus, such as human CD4 or a small molecule ligand which binds to one or more viral surface proteins of an enveloped virus.