| 摘要 |
<p>The use of N5-substituted 5-amino-1,3,4-thiadiazole-2-thiols as metalloproteinases to inhibit matrix metalloproteinase enzymes and cartilage degradation is disclosed. Methods of treating diseases caused by over-activity of matrix metalloproteinases, such as osteoarthritis and rheumatoid arthritis, are also disclosed.</p> |
