摘要 |
The present invention relates to a liquid pharmaceutical composition for injection containing docetaxel. The composition of the present invention contains (A) docetaxel and a pharmaceutically acceptable salt, (B) a surface active agent selected from polysorbate, polyoxyethylene glycol ester and polyoxyethylene castor oil derivatives, (C) a solvent containing anhydrous ethanol in the range of concentration of 100 to 800mg/ml in an injection solution, and (D) a pH adjuster of the amount suitable for adjusting pH of the liquid composition to 5 or lower. The composition of the present invention can be directly diluted in a perfusion liquid even without using an intermediary dilute solution in cases where the composition of the present invention is used as injectable preparations as the composition is formed into a single liquid phase. Further, the composition of the present invention is suitable for effective injection of docetaxel as the pharmaceutical stability of the composition is significantly improved.
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申请人 |
DONG-A PHARM.CO.,LTD.;YOO, MOO-HI;CHA, BONG-JIN;KIM, JEONG-HOON;JANG, SUN-WOO;WON, DONG-HAN |
发明人 |
YOO, MOO-HI;CHA, BONG-JIN;KIM, JEONG-HOON;JANG, SUN-WOO;WON, DONG-HAN |