| 发明名称 |
EPITOPE SYNCHRONIZATION IN ANTIGEN PRESENTING CELL |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method and a composition for accelerating a long term and directed cytotoxic T cell response against a target cell by inducing for an antigen-presenting cell to provide a specific epitope to the specific target cell. <P>SOLUTION: An epitope cluster is provided, wherein the cluster is originated from an antigen related to the target and includes or encodes at least 2 sequences having known or predictable affinity to a groove to which MHC receptor peptide binds. <P>COPYRIGHT: (C)2010,JPO&INPIT |
| 申请公布号 |
JP2009279006(A) |
申请公布日期 |
2009.12.03 |
| 申请号 |
JP20090181120 |
申请日期 |
2009.08.03 |
| 申请人 |
MANNKIND CORP |
发明人 |
SIMARD JOHN J L;DIAMOND DAVID C |
| 分类号 |
C12N15/09;A61K31/7088;A61K31/7105;A61K31/711;A61K38/00;A61K39/00;A61K39/39;A61K48/00;A61P1/16;A61P31/04;A61P31/10;A61P31/12;A61P31/18;A61P31/22;A61P33/00;A61P35/00;A61P35/02;A61P37/04;C07K5/00;C07K7/00;C07K9/00;C07K14/00;C07K14/005;C07K14/47;C07K14/725;C12N5/08;C12N5/10 |
主分类号 |
C12N15/09 |
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