IMPROVED PREPARING METHOD OF (S)-OMEPRAZOLE FROM OMEPRAZOLE RACEMATE USING OPTICAL RESOLUTION AGENT

摘要

The present invention relates to an improved preparing method of (S)-omeprazole from omeprazole racemate. In an exemplary embodiment, the preparing method according to the present invention comprises the steps of: a) reacting omeprazole racemate with optically active diethyl-D-tartrate and a titanium compound in an alcohol solvent to prepare an omeprazole racemic complex; b) reacting the omeprazole racemic complex with 1.5-3.0 molar equivalents of (S)-(+)-mandelic acid as optical resolution agent to prepare an optically active (S)-omeprazole complex; and c) dissociating the optically active (S)-omeprazole complex with a basic solution to prepare an (S)-omeprazole free base or reacting the (S)- omeprazole free base with a metal salt to transfer to a metal salt or a metal salt hydrate of (S)- omeprazole. With optical purity of 99.0 %ee or better, the (S)-omeprazole, the metal salt thereof or the hydrate thereof prepared in accordance with the present invention is useful as a medicinal material.