发明名称 |
Terminal complement inhibitor fusion proteins |
摘要 |
Nucleic acid sequences encoding chimeric proteins that comprise a functional portion of a parent terminal complement inhibitor, such as CD59, and a heterologous transmembrane domain are provided. The parent terminal complement inhibitor is modified to inactivate its GPI signal sequence. The heterologous transmembrane domain serves to anchor the chimeric protein to the cell membrane without substantially interfering with the complement inhibitor activity of the terminal complement inhibitor. The nucleic acid sequences and encoded chimeric proteins can be used to protect cells from complement attack.
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申请公布号 |
US5847082(A) |
申请公布日期 |
1998.12.08 |
申请号 |
US19950482148 |
申请日期 |
1995.06.07 |
申请人 |
ALEXION PHARMACEUTICALS, INC. |
发明人 |
ROTHER, RUSSELL;ROLLINS, SCOTT;SQUINTO, STEPHEN P. |
分类号 |
A01K67/027;A61K35/12;A61K35/76;A61K38/00;A61P37/00;C07H21/04;C07K14/03;C07K14/47;C07K14/705;C07K14/81;C07K19/00;C12N5/10;C12N15/09;C12P21/02;C12R1/91;(IPC1-7):C07K14/435;C12N15/62 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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