SCREENING METHOD FOR AGENTS SUITABLE FOR PROPHYLAXIS AND THERAPY OF ALZHEIMER'S DISEASE (AD)

摘要

Described is a method of screening for a therapeutic agent useful in the prophylaxis or treatment of AD comprising detecting oligomers of a peptide comprising an APP-G29XXXG33 motif in an assay system to which system a test compound has been added and comparing the size distribution of the oligomers of said peptide and/or degree of oligomerization with a control assay characterized by the absence of said test compound, wherein reduction of the amounts of dimers and/or tetramers indicates that said test compound might be suitable for prophylaxis or treatment of AD.