发明名称 |
Inhibitors for Extracellular Signal-Regulated Kinase Docking Domains and Uses Therefor |
摘要 |
Provided herein are compounds and methods of using compounds that selectively inhibit binding to one or more docking domain regions of an extracellular signal-recognition kinase to inhibit in a cell having an extracellular signal-regulated kinase activity. Such methods may be used to inhibit cell proliferation of a neoplastic cell, to treat a cancer and further may be used in conjunction with administration of an anticancer drug at a reduced dosage to treat a cancer with a concomitant reduction in toxicity to an individual receiving the treatment. Also provided is a method to design and screen for compounds to inhibit binding within the extracellular signal-regulated kinase docking domain region, using at least in part computer-aided drug design modeling.
|
申请公布号 |
US2009299063(A1) |
申请公布日期 |
2009.12.03 |
申请号 |
US20060887611 |
申请日期 |
2006.03.29 |
申请人 |
SHAPIRO PAUL;MACKERELL JR ALEXANDER D |
发明人 |
SHAPIRO PAUL;MACKERELL, JR. ALEXANDER D. |
分类号 |
C07D413/12;C07D241/04;C07D265/30;C07D417/04 |
主分类号 |
C07D413/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|