TARGETING TGF-ß AS A THERAPY FOR ALZHEIMER'S DISEASE

摘要

The invention includes compositions and methods for enhancing peripheral macrophage Aß phagocytosis activity. The invention includes inhibiting a component of TGF-ß signaling pathway in peripheral macrophages to promote central nervous system infiltration and beneficial cerebral Aß clearance. Inhibition of TGF-ß signaling in peripheral macrophages represents an advantageous anti-amyloid therapeutic approach for Alzheimer's disease.