Process for the glycosidation of colchicine and thiocolchicine

摘要

A process for the preparation of compounds having formula I is disclosed, wherein:
- R 1 is a methoxy or methylthio group;
- R 2 is a O-glycosyloxy residue. Compounds having formula I are prepared by reacting the corresponding precursor having R 2 = OH and the suitably protected 1-acetyl-glycose.