SULFONAMIDES AND THEIR USE AS A MEDICAMENT

摘要

The present invention relates to the use of a sulfonamide compound of formula I:
wherein
R 1 is selected from the group consisting of H, CN, halogen, trifluoromethyl, methyl, ethyl, hydroxyl, methoxyl, ethoxyl, morpholinyl, R 2 is selected from H, phenyl, substituted phenyl, CN, -SO 2 R, wherein R is phenyl or morpholinyl, -NC(O)Me, -NC(O)Et, - CH 2 C(O)OMe, CH 2 C(O)OEt, R 3 is selected from the group consisting of H, NO 2 NH 2 , halogen, -COOMe, -COOEt, RC(O)N-, morpholino, R 4 is selected from the group consisting of H, a branched or unbranched methyl, ethyl, propyl, butyl, pentyl, methoxyl, ethoxyl, propoxyl, butoxyl, a substituted or unsubstituted phenyl, alkynyl, Me 2 SO 2 -, COOR, wherein R is a branched or unbranched methyl, ethyl, propyl, butyl, pentyl, - MeOC(O)-, a substituted or unsubstituted five or six-membered aromatic or non-aromatic heterocyclic system with one , two or three heteroatoms, a heteroaryl system, a condensed benzoheterocyclic system, X is a linker comprising 2 or 3 atoms, selected from the group consisting of -NH-NH-, -NH-NH-CH 2 -, ethynyl, -NH-C(O)-CH 2 -, -NH-NH-SO 2 - -C(O)-NH-CH 2 -, -NH-N=CH-, -NH-N=C(Me)-, a -NH-N=CH- motif being part of a heterocyclic system, preferably a substituted or unsubstituted pyrazole or pyridazine system, and pharmaceutically active salts thereof. Further, the invention relates to the use of these compounds as a medicament, especially for the treatment of cancer.