发明名称 |
A METHOD FOR IMPROVING THE PHARMACOKINETICS OF DRUGS METABOLIZED BY UGT2B10 |
摘要 |
A method for modifying the pharmacokinetics of a pharmacologically active agent that undergoes direct N-glucuronidation by UDP-glucuronosyltransferase isoenzyme UGT2B10 in a human subject comprising administering an effective amount of an UGT2B10 modulator to said human subject. A method for identifying compounds which are directly metabolized by UGT2B10 or which act as UGT2B10 modulators is also disclosed. |
申请公布号 |
EP2124939(A1) |
申请公布日期 |
2009.12.02 |
申请号 |
EP20080718487 |
申请日期 |
2008.01.29 |
申请人 |
ORION CORPORATION |
发明人 |
KAIVOSAARI, SANNA;FINEL, MOSHE |
分类号 |
A61K31/4174;A61K31/465 |
主分类号 |
A61K31/4174 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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