发明名称 |
Corticosteroid containing liposomes for treatment of cardiovascular diseases |
摘要 |
The invention provides a use of a long-circulating microvesicle comprising a sterol, partially synthetic or wholly synthetic vesicle-forming phospholipids, and a corticosteroid in water soluble form, which microvesicle has a mean particle diameter size range of between about 75 and 150 nm and which microvesicle is non-charged or negatively charged at physiological conditions, for the preparation of a medicament for the treatment of atherosclerosis and/or cardiovascular disease. A method for treating a subject suffering from, or at risk of suffering from, atherosclerosis and/or cardiovascular disease, comprising administering to said subject a therapeutically effective amount of such long-circulating microvesicles is also provided. |
申请公布号 |
EP2127639(A1) |
申请公布日期 |
2009.12.02 |
申请号 |
EP20080156887 |
申请日期 |
2008.05.26 |
申请人 |
UNIVERSITEIT UTRECHT HOLDING B.V.;MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY |
发明人 |
MULDER, WILLEM JAN MENNO;FAYAD, ZAHI ADEL;STORM, GERRIT;METSELAAR, JOSBERT MAARTEN |
分类号 |
A61K9/127;A61K31/573;A61P9/10 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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