| 摘要 |
<p>[Problem] An object of the present invention is to provide a method of testing the integrity of a microporous membrane using a colloid solution containing metal particles or metal compound particles that can accurately determine the integrity of a virus removal membrane formed of hydrophilized synthetic polymer that has been subjected to protein solution filtration, and to provide a method of producing the colloid solution. [Means for Solving Problem] A method of testing the integrity of a microporous membrane comprising filtering a colloid solution through a microporous membrane, the colloid solution comprising a solvent and metal particles dispersed in the solvent, and the solvent comprising components (A) and (B), (A) and (C), or (A), (B), and (C), wherein the component (A) is an anionic polymer having a sulfonic acid group, the component (B) is at least one nonionic surfactant selected from the group consisting of a nonionic surfactant having a polycyclic structure in a hydrophobic moiety and a polyoxyethylene sorbitan fatty acid ester, and the component (C) is a water-soluble polymer having a pyrrolidone group.</p> |
