发明名称 |
Indolo[2,3-b]-, Indeno[1,2-b]- and Indeno[2,1-b]pyrido[2,3-f] quinoxaline-3-carboxylic acids and esters, processes for their preparation and their use as antiviral, antibiotic and antitumor agents |
摘要 |
<p>The present invention relates to novel quinoxaline derivatives represented by regioisomeric structures of quinoxalines of general formulas I and/or II,
wherein the COOR 1 group independently is an acid, an ester and/or a salt, Y 1 and/or Y 2 are independently halogen and/or H, in particular Y 1 is fluorine, A is oxo (C=O), C(R 3 ) 2 and/or N-R 2 , wherein each R 3 and/or R 2 independently are H, linear, branched or cyclic unsubstituted or substituted hydrocarbon and X 1 is H, halogen, linear, branched or cyclic unsubstituted or substituted hydrocarbon. The present invention relates further to a process for the production of the quinoxalines of formulas I and II, a key precursor as well as their use as pharmaceutical active agents, in particular as agents that are active against cancer, as antibiotic and/or at least one virus.</p> |
申请公布号 |
EP2128160(A1) |
申请公布日期 |
2009.12.02 |
申请号 |
EP20080008254 |
申请日期 |
2008.04.30 |
申请人 |
UNIVERSITAET DUISBURG-ESSEN |
发明人 |
BOESE, ROLAND;EL-ABADELAH, MUSTAFA M.;ZAHRA, JALAL A., DR. |
分类号 |
C07D471/04;A61K31/437;A61K31/4375;A61P31/00;A61P31/12;A61P35/00 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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