发明名称 |
NUCLEOSIDE ARYL PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION |
摘要 |
<p>The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside aryl phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside aryl phosphoramidates of the present invention. (I)</p> |
申请公布号 |
EP2124555(A2) |
申请公布日期 |
2009.12.02 |
申请号 |
EP20070868112 |
申请日期 |
2007.12.28 |
申请人 |
MERCK & CO., INC.;ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. |
发明人 |
NARJES, FRANK;GARDELLI, CRISTINA;DONGHI, MONICA;ATTENNI, BARBARA;DURETTE, PHILIPPE, L. |
分类号 |
C07H19/04;A01N43/04;A61K31/70;C07H19/048;C07H19/10;C07H19/20 |
主分类号 |
C07H19/04 |
代理机构 |
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代理人 |
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地址 |
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